Synthetic membrane

made of polylactic acid

The unique resorbable membrane structure with multiple applications:
GTR (Guided Tissue Regeneration)
GBR (Guided Bone Regeneration)

Three-Layer Technology
The patented barrier matrix is characterized by its unique three-dimensional architecture. This internal structure creates a three-dimensional gradient of density designed to allow fibroblasts and epithelial cells to enter the hollow spaces and to attach themselves to the walls, stabilizing these cells in the process. The innovative structure is easily recognizable in the cross-section: The inner layer, featuring large and closed pores, transforms into a chamber-like structure in the intermediate layer and then into the highly porous outer layer, also featuring large pores.


Treatment of dental furcations


Easy Handling


Epi-Guide can be perfectly cut to size for any defect using scissors or a scalpel. Once in contact with blood, the barrier matrix will become flexible and easily adaptable to the site. The structured embossed surface should face the soft tissue. The blood-soaked barrier matrix attaches closely to the tooth; in most cases, it will be unnecessary to hold the matrix in place with a suture. For a better adhesiveness, it is recommended to leave it immersed in a saline solution for 30 minutes before the use.


Structure and Characteristics


The Epi-Guide barrier matrix comes in 18 x 30 mm (0.7 x 1.2 in.) rectangles. For easier orientation, the surface facing the soft tissue has an embossed textured surface. Epi-Guide is highly hydrophilic and will accommodate a large amount of blood in the intermediate chamber layer specifically designed for this purpose. The patented three-layer barrier matrix contains a layer that prevents ingrowth. of epithelial cells. In this manner, the barrier matrix serves as a placeholder for the development of bone and periodontal tissue. An evenly distributed blood clot is formed where the gingiva, the barrier matrix, and the tooth tissue meet which counteracts flap recession and pocket formation.


Resorption Behavior


It was shown in histological examinations performed six weeks postoperatively that inflammation-free collagen fibres had formed in the barrier matrix. The architecture and structure of the barrier had remained stable. After three weeks, as the formation of collagen fibres continues, biosorption sets in; the matrix, however, continues to serve its function. After approximately 12 months, Epi-Guide® will have been completely resorbed. No second stage surgery is required. Suture dehiscences and a slight gingival recession are very well tolerated by Epi-Guide. The membrane surface with its open and interconnected pores counteracts suture dehiscences and gingival recession.


It is a synthetic membrane, bioresorbable based on polylactic acid. Tri-Layer technology: the first rough layer touches the mucous membrane, it is characterized by wide grooves. It inhibits the infiltration of fibroblasts facilitating cell adhesion. The interlayer, with a labyrinth structure, supports the formation of collateral vessels and the flow of interstitial fluid. It provides the stabilization of fibroblasts. The third layer is in direct contact with the osseous part; closed pores allow it to absorb blood and adhere to the tooth surface, promoting the gingival attachment

Dimensions: 18 x 30 mm


Slow reabsorption, barrier effect in 20 weeks. Complete reabsorption between six and twelve months; Unique tri-layer; It can be left exposed.


Function and Application


Following careful preparation of the implant site (granulation tissue must be removed), scissors or a scalpel are used to trim the Epi-Guide membrane to size, making sure that the defect is sufficiently covered. The material should overlap the defect by 2-3 mm each on the mesial, distal, and apical aspects, but not on the coronal aspect. The embossed side is designed to face away from the tooth surface so that the flat side of the barrier matrix attaches to the tooth surface. As soon as the Epi-Guide® membrane is exposed to blood, it will become very sticky. A suture will not be necessary for most situations, although the surgeon may certainly provide one at his or her discretion.




Epi-Guide consists of lactic acid polymers. The polymer structure (D, D-L, L-polylactide) breaks down into carbon dioxide (CO ) and water (HO). That polylactic acid (PLA) is safe and innocuous has been demonstrated in numerous toxicological studies and in vitro and in vivo studies of biocompatibility on several animal species as well as in vivo studies on humans. PLA is an immunologically inactive substance. Because of their biological and mechanical properties, PLA polymers have been used for widely divergent therapeutic applications for many years, invariably demonstrating their biocompatibility, bio-logical resorption ability, and absence of toxicity.


Clinical studies
with Epi-Guide®


A multicenter study about bone tissue regeneration in class II furcations treatment has been conducted on 40 patients with bilateral defects. The aim was to evaluate the impact of three-dimensional Epi-guide barrier and Guidor. The quantity and the quality of the new bone have been evaluated one year after, during the postoperative. This evaluation, that took place in 3 different centres, has shown better results for Epi-Guide® concerning the reduction in the vertical component. The same study also showed that, within the first 8 weeks, the exposure has occurred less in Epi-Guide® than Guidor.

layer 1


This layer consists of closed pores and ensures that generous amounts of blood are adsorbed, at the same time facilitating the adaptation of the membrane to the tooth surface. This layer also serves as a barrier, preventing the migration of fibroblasts and apical ingrowth of epithelial cells. By doing so, it promotes gingival attachment.

layer 2


A well-organized blood clot forms inside the labyrinthine structure between the two different outer surfaces. This supports the formation of collateral vessels and an unrestricted flow of interstitial fluid. The hollow spaces, which are irregular in shape and size, form a framework for the apposition and stabilization of fibroblasts, actively supporting the healing process.

layer 3


The outer surface with its embossed textured surface consists of large inter-connective pathways. The inner structure decelerates fibroblasts infiltration and improves cell apposition. Histological examinations have demonstrated connective tissue entering the internal matrix structure, depositing collagen fibres.

18 x 30 mm

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